May 2021: Jasmine King
Jasmine King, a graduate student in the Bioengineering program, member of the McDevitt Lab and a Career and Development Officer for BE-STEM, presented the talk titled: Modeling the Impact of the Autonomic Nervous System on the Development of Human iPSC-Sinoatrial Nodal Cells
Abstract: My research in the McDevitt Lab focuses on developing an iPSC-derived model of the Sinoatrial Node (SAN) to study the influence of innervation on SAN development and responsiveness to neuronal stimulation. The SAN is innervated by the autonomic nervous system; furthermore, the timing and chronology of cardiac innervation are evolutionarily conserved among most mammals, which suggests an important role for innervation in cardiac development. It has been difficult to study SAN innervation in vivo because chemical denervation approaches have systemic repercussions, and surgical denervation is technically challenging. To address the challenges of SAN models, I am leveraging the capabilities of iPSCs in order to study the impact of the autonomic nervous system on the development of iPSC-sinoatrial nodal cells.